Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Recruiting now · Phase 1/Phase 2

Conditions studied: Age-Related Macular Degeneration, Geographic Atrophy, Non-neovascular AMD

In brief

The Phase 1 safety study of VOY-101 comprises of escalating dose Cohorts, followed by a Phase 2a.

Key facts

Study ID

NCT06087458

Run by

Perceive Biotherapeutics, Inc.

People needed

60

Starts

2023-06-21

Expected to finish

2028-03-01

Last updated by the study team

2025-10-15

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are ≥60 years of age at the time of consent.
• Are willing and able to understand and provide written informed consent.
• Are willing and able to return for scheduled treatment and follow-up examinations.
• Are able to undergo ETDRS BCDVA testing and ophthalmic imaging.
• Well-demarcated GA secondary to AMD in the absence of MNV and in the absence of history of MNV for both eyes.
• Absence of signs of non-exudative MNV.
• Additional Ocular Inclusion Criteria for both eyes.
• Meet certain genotype criteria for risk of AMD.

You may not qualify if…

• Are women of childbearing potential (WOCBP) and are pregnant or unwilling to use and document use of effective contraception for the duration of the study.
• Additional Systemic, Ocular, and Genetic Exclusion Criteria.

Where it is running

• Tel-Aviv Sourasky Medical Center, Ophthalmology Division — Tel Aviv, Israel (enrolling)
• The Retina Partners — Encino, California, United States (enrolling)
• Retinal Consultants Medical Group — Sacramento, California, United States (enrolling)
• Retina Consultants San Diego — San Diego, California, United States (enrolling)
• Star Retina — Burleson, Texas, United States (enrolling)
• Retina Center of Texas — Southlake, Texas, United States (enrolling)
• University of Utah John A. Moran Eye Center — Salt Lake City, Utah, United States (enrolling)
• Rambam Medical Center — Haifa, Israel (enrolling)
• Retina Macula Institute of AZ — Scottsdale, Arizona, United States (enrolling)
• Sydney Retina Clinic and Day Surgery — Sydney, New South Wales, Australia
• Cerulea Clinical Trials — East Melbourne, Victoria, Australia

Full record on ClinicalTrials.gov

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