Cognitive Rehabilitation Therapy for COVID-19

Enrolling by invitation · Not applicable

Conditions studied: Post-Acute COVID-19 Syndrome

In brief

Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans' community functioning and quality of life, contribute to significant human suffering, and are costly to VHA. Rehabilitation is a critical priority for Veterans with long COVID. One promising treatment to improve functioning in Veterans with post-COVID-19 cognitive symptoms is Compensatory Cognitive Training (CCT). Previous studies have found that CCT is feasible, acceptable, and efficacious in Veteran populations with multiple sources of cognitive dysfunction. This randomized controlled trial aims to address important RR\&D priorities by examining feasibility, acceptability, and preliminary efficacy of a COVID-19-specific rehabilitation intervention, CCT for long COVID (CCT-C) compared to a robust control condition. The proposed study has the potential to improve cognitive function, functional independence, and quality of life for Veterans with late or delayed effects of secondary conditions related to COVID-19 infections.

Key facts

Study ID

NCT06086379

Run by

VA Office of Research and Development

People needed

70

Starts

2024-07-01

Expected to finish

2029-03-31

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans > 18 years old who are able to provide informed consent
• Prior participation in SF Parent Study or LA Parent Study
• Report of cognitive symptoms that Veteran attributes to COVID-19 infection

You may not qualify if…

• Current substance abuse disorder, psychotic disorder, dementia, etc.
• History of moderate to severe brain injury with loss of consciousness > 30 minutes
• Auditory or visual impairments that would prevent the ability to participate in assessment procedures
• Invalid performance on one or more embedded performance validity tests (PVTs)

Where it is running

• VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States

Full record on ClinicalTrials.gov

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