Evaluation of a Brief Computerized and Smart Phone-based Intervention for Stress in Regular Cannabis Users

Recruiting now · Not applicable

Conditions studied: Cannabis Use Disorder

In brief

The prevalence of daily cannabis use and Cannabis Use Disorder (CUD) has increased in the United States over the past two decades. Brief, computerized harm reduction interventions that target specific high-risk CUD populations could be an efficient approach to reducing CUD. Distress intolerance , which refers to the tendency to negatively appraise and escape aversive emotional states, is a risk factor associated with stress-related cannabis use motivation and CUD severity/chronicity. Thus, a brief, accessible, low-cost intervention that reduces distress intolerance in those with CUD and elevated distress intolerance could have a significant public health impact. This proposed project aims to optimize an existing two-session computerized distress tolerance intervention and test its impact on distress intolerance and cannabis use outcomes in a randomized controlled trial. Specifically, the intervention will be condensed to one-session, its active ingredient bolstered, and augmented with smart phone-delivered therapy reminders. After obtaining feedback on the modified Emotional Engagement Distress Tolerance Intervention in a small sample, the intervention's efficacy compared to a stringent, credible, time-matched health education control intervention will be tested in a randomized controlled trial in 80 cannabis users with CUD and high distress intolerance. Distress intolerance, cannabis use, and psychosocial functioning outcomes will be evaluated. As an exploratory aim, a wristworn device will be used to measure objective stress responding in the real-world during the intervention period. Our central hypothesis is that, compared to a control intervention, the Emotional Engagement Distress Tolerance Intervention will produce superior reductions distress intolerance, stress-related cannabis use motivation, disordered cannabis use, and psychosocial functioning.

Key facts

Study ID

NCT06085222

Run by

Florida State University

People needed

80

Starts

2024-06-04

Expected to finish

2027-10-30

Last updated by the study team

2025-09-22

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cannabis is the primary substance of abuse.
• Clinical-level Distress intolerance Index score.
• Current Cannabis Use Disorder diagnosis.
• Near-daily to daily cannabis use in past-month and past 3 months.
• Positive urine screen for THC
• Detectable skin conductance level
• Owns a smart phone
• Primary smoked/vaporized delta-9 or delta-8 THC user

You may not qualify if…

• Presence of acute/major psychiatric disturbance
• Current pregnancy
• Change in psychotropic medication within the past month
• Concurrently receiving treatment for cannabis use
• Concurrently receiving dialectical behavior therapy or exposure-based therapy for emotional disorders
• Planning to immediately quit using cannabis
• EEG contraindications
• Kidney disease

Where it is running

• The BRAINS Lab at Florida State University — Tallahassee, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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