Longitudinal Recovery Trajectories After an Acute Respiratory Distress Syndrome, a New Understanding
Recruiting now
Conditions studied: ARDS, ARDS Disease Progression
In brief
COVID-19 resulted in the largest cohort of critical illness survivors in history, heightened awareness of the importance of the respiratory sequelae after an acute distress respiratory syndrome (ADRS). Despite the advancement of acute-phase ARDS management, it is unknown whether there are differences in the longitudinal recovery trajectories between patients with post-ARDS due to COVID-19 and due to other causes. The main objective of the study is to identify risk factors of pulmonary sequela (lung diffusing capacity) at long-term follow-up in survivors of ARDS. The investigators are also interested in describing the long-term longitudinal recovery trajectories at a multi-dimensional level (symptoms, quality of life, neurocognitive, other lung function parameters, exercise capacity, chest imaging and molecular profiles) of ARDS survivors, and compared between ARDS caused by COVID-19. The ultimate goal is to understand the pathobiological mechanisms associated with a severe lung injury at the long term, allowing the introduction of clinical guidelines for the management of post-ARDS patients and the assignment of personalized interventions.
Key facts
- Study ID
- NCT06083363
- Run by
- Institut de Recerca Biomèdica de Lleida
- People needed
- 246
- Starts
- 2023-06-29
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2024-03-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female patients aged ≥18 years
- Admission to the ICU
- Diagnosis of severe pneumonia and/or diagnosis of acute respiratory distress syndrome (ARDS) based on the 2023 definition due to any origin (infectious and non-infectious)
You may not qualify if…
- Life expectancy less than a year
- Transfer to another hospital during hospitalization or follow-up
- Stay in palliative care
- Severe mental disability that makes it impossible to carry out pulmonary function tests during follow-up
Where it is running
- Hospital de Tortosa Verge de la Cinta — Tortosa, Tarragona, Spain (enrolling)
- Hospital Universitari Arnau de Vilanova — Lleida, Spain (enrolling)
- Hospital Universitari Joan XXIII — Tarragona, Spain (enrolling)
Full record on ClinicalTrials.gov
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