Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users

Recruiting now · Not applicable

Conditions studied: Cannabis User

In brief

The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.

Key facts

Study ID

NCT06081218

Run by

University Hospital, Lille

People needed

60

Starts

2024-05-07

Expected to finish

2029-12-31

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Cannabis consumer group:
• Cannabis consumption > 100 times in lifetime, last exposure < 7 days, and recent exposure > 10 times in the month.
• Positive toxicological urine test for ∆-9-THC.
• Having a cannabis use disorder according to the CAST.
• Healthy group:
• Negative urine toxicological test for cannabis.
• No regular cannabis use for more than 6 months once in a lifetime.
• No cannabis consumption in the 6 months preceding the study.

You may not qualify if…

• For all subjects :
• Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
• Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
• Under medical treatment.
• Presence of diagnosed neurological disorders.
• Diagnosis of a psychotic picture entering axis I, DSM-5.
• Chronic progressive disease or in remission.
• Body mass index > 30 kg/m2 (i.e. presence of obesity).

Where it is running

• CHU Lille — Lille, France (enrolling)

Full record on ClinicalTrials.gov

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