Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Status unconfirmed
Conditions studied: Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode, Depressive Symptoms, Anhedonia
In brief
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.
Key facts
- Study ID
- NCT06080646
- Run by
- San Francisco Veterans Affairs Medical Center
- People needed
- 150
- Starts
- 2021-06-01
- Expected to finish
- 2025-09-01
- Last updated by the study team
- 2024-08-02
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-70 years with a diagnosis of major depressive disorder (MDD) for MDD group, or without for unaffected comparison (UC) group
- Negative metal screen for MRI safety
- Normal (or corrected to normal) vision
You may not qualify if…
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms)
- Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
- Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions
- Known claustrophobia
- Current Pregnancy
- IQ estimate < 70
Where it is running
- San Francisco Healthcare System — San Francisco, California, United States (enrolling)
Full record on ClinicalTrials.gov
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