Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects With Chronic Spontaneous Urticaria

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Chronic Spontaneous Urticaria

In brief

Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects with Chronic Spontaneous Urticaria

Key facts

Study ID

NCT06077773

Run by

Escient Pharmaceuticals, Inc

People needed

113

Starts

2023-09-25

Expected to finish

2025-01-16

Last updated by the study team

2025-12-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented history of chronic spontaneous urticaria (CSU) with a UAS7 greater than or equal to 16 despite stable treatment with H1 antihistamine consistent with standard of care
• Must be on a stable dose of H1 antihistamine up to 4 times the approved dose per local treatment guidelines

You may not qualify if…

• Urticaria with a clear underlying etiology other than CSU
• Urticaria with a clearly defined or sole trigger (chronic inducible urticaria)
• Other active skin diseases associated with chronic pruritus (eg, atopic dermatitis, bullous pemphigoid, prurigo nodularis, dermatitis herpetiformis)

Where it is running

• AllerVie Clinical Research — Birmingham, Alabama, United States
• Scottsdale Clinical Trials — Scottsdale, Arizona, United States
• Little Rock Allergy & Asthma Clinical Research Center — Little Rock, Arkansas, United States
• First OC Dermatology Research, Inc. — Fountain Valley, California, United States
• Allergy and Asthma Specialists Medical Group — Huntington Beach, California, United States
• Antelope Valley Clinical Trials — Los Angeles, California, United States
• Allervie Clinical Research — Destin, Florida, United States
• University of Miami Itch Center — Miami, Florida, United States
• Florida Center for Allergy and Asthma Research — Miami, Florida, United States
• NuLine Clinical Trial Center — Pompano Beach, Florida, United States
• Advanced Clinical Research Institute — Tampa, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Treasure Valley Medical Research — Boise, Idaho, United States
• Dawes Fretzin Clinical Research Group, LLC — Indianapolis, Indiana, United States
• Southern Indiana Clinical Trials — New Albany, Indiana, United States
• The Indiana Clinical Trials Center — Plainfield, Indiana, United States
• Velocity Clinical Research, Overland Park, KC Asthma & Allergy — Overland Park, Kansas, United States
• Allergy & Asthma Specialists, P.S.C. — Owensboro, Kentucky, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Chesapeake Clinical Research, Inc. — White Marsh, Maryland, United States
• The Clinical Research Center LLC — St Louis, Missouri, United States
• Montana Medical Research, Inc. — Missoula, Montana, United States
• Las Vegas Clinical Trials — North Las Vegas, Nevada, United States
• Corning Center for Clinical Research — Horseheads, New York, United States
• Bobby Buka MD, PC — New York, New York, United States

Full record on ClinicalTrials.gov

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