Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

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Conditions studied: Cannabis Use, THC, Marijuana Use, Cognitive Impairment, THC Vaping

In brief

The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: * Can researchers accurately assess THC consumption among frequent cannabis users? * Can researchers effectively incentivize cannabis users to use less potent THC products? * Do genetic variations in THC metabolism impact urinary THC excretion? * Do genetic variations in THC metabolism impact cognitive performance in cannabis users? * Are quantitative urinary THC values predictive of cognitive impairment? * How can researchers use research findings to inform harm reduction practices for people who use cannabis? Participants will submit blood and urine samples and be incentivized to use less potent THC products.

Key facts

Study ID

NCT06077292

Run by

University of California, San Francisco

People needed

110

Starts

2025-03-17

Expected to finish

2026-12-14

Last updated by the study team

2026-04-13

Who can join

Age: 21 and older, up to 25. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 21-25
• Resides in San Francisco
• Self-report cannabis concentrate use as their primary method of cannabis use
• Self-report using cannabis daily or almost daily (i.e., at least 6 out of 7 days during each of the last 4 weeks)
• Self-report only purchasing cannabis from regulated retail stores in California.

You may not qualify if…

• Pregnant
• Regularly uses other drugs (other than nicotine)

Where it is running

• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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