A Retrospective Study on the Relationship Between Donor Leukocyte Telomere Length and Prognosis of Acute Leukemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation

Recruiting now

Conditions studied: Acute Leukemia

In brief

This post hoc analysis included patients with acute leukemia who underwent allo-HSCT at the First Affiliated Hospital of Zhejiang University School of Medicine and Ruijin Hospital Shanghai Jiaotong University School of Medicine. Patients and their donors were assessed for eligibility to join this study. The inclusion criteria were: (1) age ≥ 5 years; (2) diagnosis of acute leukemia including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia; (3) patients attained complete remission (CR) and achieved full engraftment with 100% donor chimerism following allo-HSCT; (4) telomere testing was conducted on peripheral leukocytes of donors before granulocyte colony-stimulating factor (G-CSF) mobilization, and the results were obtained. Written informed consent was obtained from all included patients and their donors, and the study was conducted in compliance with the Declaration of Helsinki. Ethical approval was approved by the ethics review committee of the First Affiliated Hospital of Zhejiang University School of Medicine.

Key facts

Study ID

NCT06076226

Run by

Zhejiang University

People needed

2500

Starts

2015-01-01

Expected to finish

2026-12-01

Last updated by the study team

2023-10-10

Who can join

Age: 5 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 5 years
• First allo-HSCT from matched related, unrelated, or haploidentical donors
• Achievement of complete remission after allo-HSCT
• Donor blood sample collection before granulocyte colony-stimulating factor mobilization

You may not qualify if…

• Non-acute leukemia diagnoses, including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia
• Failure to achieve engraftment with full donor chimerism after allo-HSCT
• Inability to extract DNA for telomere length analysis.

Where it is running

• Clinical research ethics committee of the first affiliated hospital, college of medicine, zhejiang University — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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