Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Sleep Deprivation, Nutritional Intervention

In brief

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).

Key facts

Study ID

NCT06075914

Run by

Ohio State University

People needed

60

Starts

2023-05-01

Expected to finish

2027-02-01

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy, 18-40 years old.
• BMI: 20-35 kg/m2
• Sleep at least 7h per night.
• Willing to participate in \~9-weeks of testing and provided food.
• Willing to adhere to all study procedures.

You may not qualify if…

• <18 or >40 years of age
• >35 body mass index (BMI).
• Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
• Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
• Drink alcohol in excess of 3 drinks/day or 14 drinks/week
• Have any conditions or contraindications to blood draws.
• Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
• Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
• Have experienced weight loss of >10% of your body weight within the last 6 months
• Are pregnant, lactating, or planning on becoming pregnant during the study
• Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

Where it is running

• The Ohio State University — Columbus, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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