Hyaluronic Filler for Improvement of Radial Cheek Lines

Completed · Not applicable

Conditions studied: Aging

In brief

Appearance of superficial radial cheek lines and fine lines of the cheek are signs of photoaging. These lines appear in a curvilinear or crosshatched fashion on the lower cheeks in photoaged individuals. They represent a common concern among patients seeking cosmetic treatments. With the aging population and increasing social awareness of cosmetic treatments, it is likely that the demand for filler procedures will increase. Current treatment options for these lines include fractionated and fully ablative laser resurfacing, topical retinoids, intradermal filler injections, and chemical peels. One potential treatment for facial fine lines include use of low G' hyaluronic acid fillers, which allow for dynamic movement while also addressing the appearance of the lines. Resilient Hyaluronic Acid (RHA) Redensity is an FDA-cleared filler used for treatment of dynamic perioral rhytids. Hyaluronic acid-based fillers have been shown to improve overall skin texture (skin surface hydration, roughness, and elasticity) through the hypothesized mechanism of inducing a fibroblast response to boost collagen production. They have the potential to reduce appearance of facial fine lines of the cheek. This study will evaluate the efficacy of RHA Redensity in improving radial cheek lines.

Key facts

Study ID

NCT06074302

Run by

Main Line Center for Laser Surgery

People needed

20

Starts

2023-11-01

Expected to finish

2024-11-01

Last updated by the study team

2025-10-29

Who can join

Age: 31 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 31 years old or great
• Rating of 2, 3, or 4 on 5-point Allergan Fine Lines Scale on the cheeks

You may not qualify if…

• Pregnancy
• Prior adverse reaction to hyaluronic acid treatment (injectable or over-the-counter topical)
• Connective tissue disorder
• Active infection in treatment area
• Active severe inflammatory disease in treatment area such as atopic dermatitis, psoriasis
• Treatment with toxin or filler in lower face below the orbital rim within the past 6 months

Where it is running

• Main Line Center for Laser Surgery — Ardmore, Pennsylvania, United States

Full record on ClinicalTrials.gov

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