Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
Running, not enrolling · Phase 3
Conditions studied: CLL
In brief
The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)
Key facts
- Study ID
- NCT06073821
- Run by
- BeOne Medicines
- People needed
- 652
- Starts
- 2023-11-11
- Expected to finish
- 2032-12-01
- Last updated by the study team
- 2026-08-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Treatment-naïve (TN) adults with confirmed diagnosis of CLL which requires treatment
- Eastern Cooperative Oncology Group (ECOG) score 0, 1, or 2
- Measurable disease by Computer Tomography/Magnetic Resonance Imaging
- Adequate liver function as indicated by aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x the institutional upper limits of normal (ULNs) value; serum total bilirubin < 3.0 x ULN
- Adequate renal function as defined as creatinine clearance ≥ 50 milliliters per minute
You may not qualify if…
- Previous systemic treatment for CLL
- Known prolymphocytic leukemia or history of, or currently suspected, Richter's transformation
- Known central nervous system involvement
- History of confirmed progressive multifocal leukoencephalopathy (PML)
- Uncontrolled hypertension
- Note: Other protocol defined criteria may apply
Where it is running
- City of Hope National Medical Center — Duarte, California, United States
- University of California San Diego (Ucsd) Moores Cancer Center — La Jolla, California, United States
- Valkyrie Clinical Trials — Los Angeles, California, United States
- UCLA Department of Medicine Hematologyoncology — Los Angeles, California, United States
- Chao Family Comprehensive Cancer Center — Orange, California, United States
- Stanford Medicine — Palo Alto, California, United States
- University of Colorado Cancer Center — Aurora, Colorado, United States
- Medstar Georgetown University Hospital — Washington D.C., District of Columbia, United States
- Mount Sinai Medical Center Braman Comprehensive Cancer Center — Miami, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Southeastern Regional Medical Center — Newnan, Georgia, United States
- Northwestern University — Chicago, Illinois, United States
- Illinois Cancercare, Pc — Peoria, Illinois, United States
- Fort Wayne Medical Oncology and Hematology — Fort Wayne, Indiana, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- Mission Cancer and Blood — Waukee, Iowa, United States
- The University of Kansas Cancer Center — Westwood, Kansas, United States
- Norton Cancer Institute Pavilion — Louisville, Kentucky, United States
- Ochsner Clinic Foundation — New Orleans, Louisiana, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- John Theurer Cancer Center Hackensack University Medical Center — Hackensack, New Jersey, United States
- Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
- Columbia University Medical Center — New York, New York, United States
- Alaska Oncology and Hematology, Llc — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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