Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
Recruiting now
Conditions studied: Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
In brief
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty. In this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.
Key facts
- Study ID
- NCT06073106
- Run by
- Tan Tock Seng Hospital
- People needed
- 500
- Starts
- 2025-01-01
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2025-04-11
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 50y
- Asian ethnicity
- First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)
- Living in community
- Able to understand 1 step simple commands
- For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission
- For outpatients: (i) >6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking.
You may not qualify if…
- Nursing home or dormitory resident
- Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)
- Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,
- Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium
- Anticipated life expectancy < 1 year
- Presence of tracheostomy, ventilator, renal dialysis, end-organ failure
- Patients with disorders of consciousness.
- Pregnant or lactating participants
- For Knee Osteoarthritis patients only:
- Alternative diagnosis to knee OA e.g. Referred pain from hip or spine.
- Other forms of knee arthritis eg. Inflammatory, post traumatic
- Previous knee arthroplasty
Where it is running
- Tan Tock Seng Hospital — Singapore, Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
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