Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
Recruiting now · Not applicable
Conditions studied: Rosacea, Systemic Inflammation
In brief
The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.
Key facts
- Study ID
- NCT06072066
- Run by
- Integrative Skin Science and Research
- People needed
- 24
- Starts
- 2023-11-22
- Expected to finish
- 2024-12-31
- Last updated by the study team
- 2024-08-27
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and females 30 to 70 years of age
- The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular)
- High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg/L
You may not qualify if…
- The presence of severe rosacea as noted by the investigator global assessment.
- Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.
- Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment
- Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment.
- Those who are unwilling to keep their facial regimen the same throughout the study.
- Individuals who have been on an oral antibiotic within the previous one month.
- Individuals who are pregnant or breastfeeding.
- Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.
- Individuals on oral contraceptive pills or progesterone or estrogen containing therapies.
- Use of isotretinoin within the three months prior to enrollment.
- Individuals on finasteride or dutasteride
- Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.
Where it is running
- Integrative Skin and Research — Sacramento, California, United States (enrolling)
Full record on ClinicalTrials.gov
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