Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine

Completed · Phase 1

Conditions studied: Healthy Participants

In brief

This study will investigate the potential drug interactions between vemircopan and metformin, rosuvastatin, levonorgestrel/ ethinyl estradiol (LNG/EE)-containing oral contraceptive(s) (OCs), and carbamazepine in healthy participants.

Key facts

Study ID

NCT06071442

Run by

Alexion Pharmaceuticals, Inc.

People needed

60

Starts

2024-01-17

Expected to finish

2024-04-12

Last updated by the study team

2025-08-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants who are medically healthy with no clinically significant or relevant abnormalities as determined by medical history, physical or neurological examination, vital signs, 12-lead ECG, screening clinical laboratory profiles (hematology, biochemistry, coagulation, and urinalysis), as deemed by the Investigator or designee.
• Body weight of at minimum 50 kg and body mass index (BMI) within the range 18 to 32 kg/m\^2 (inclusive) at the Screening.
• Male and female participants should adhere to the protocol defined contraceptive methods.

You may not qualify if…

• History or presence of medical (eg, cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrinological, hematological, neurological or other disorders) or psychiatric conditions or diseases.
• History of clinically significant hypersensitivity or idiosyncratic reaction to the study drugs or related compounds.
• History of drug or alcohol abuse within 2 years prior to first dosing
• Current tobacco users or smokers (defined as any tobacco or nicotine-containing product use within 3 months prior to first dosing).
• Donation of whole blood from 3 months prior to first dose administration, or of plasma from 30 days before first dose administration.
• Female participants who have a positive pregnancy test at Screening or Day -1, or who are lactating.
• Positive drugs of abuse, cotinine, or alcohol screen at Screening or Day -1.

Where it is running

• Research Site — Brooklyn, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.