Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

Recruiting now

Conditions studied: Sickle Cell Trait

In brief

The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.

Key facts

Study ID: NCT06071377
Run by: National Alliance for Sickle Cell Centers
People needed: 1000
Starts: 2023-04-01
Expected to finish: 2027-02-01
Last updated by the study team: 2025-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Are willing to voluntarily participate and sign the study consent
Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
Adults ages 18 and older

You may not qualify if…

Unwilling to sign consent
Known end-stage renal disease or dialysis
Known SCD (including sickle cell-beta thalassemia)
People who do not have SCT

Where it is running

University of Alabama — Birmingham, Alabama, United States (enrolling)
Loma Linda University Health Care — Loma Linda, California, United States (enrolling)
Nemours Children's Hospital — Wilmington, Delaware, United States (enrolling)
Indiana University — Indianapolis, Indiana, United States (enrolling)
Functional Fluidics — Detroit, Michigan, United States (enrolling)
University of North Carolina — Chapel Hill, North Carolina, United States (enrolling)
Duke University — Durham, North Carolina, United States (enrolling)
East Carolina University — Greenville, North Carolina, United States (enrolling)
Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
UT Health Houston — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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