Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Hemorrhagic Shock, Trauma Injury
In brief
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion. The primary objective of the clinical trial is to determine the effectiveness of Low Titer Group O Whole Blood (LTOWB) compared to component therapy (CT), and Tranexamic Acid (TXA) compared to placebo in decreasing 24-hour all-cause mortality in children with traumatic life threatening hemorrhage.
Key facts
- Study ID
- NCT06070350
- Run by
- Philip Spinella
- People needed
- 1000
- Starts
- 2024-11-01
- Expected to finish
- 2028-10-01
- Last updated by the study team
- 2026-07-21
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- Arkansas Children's Hospital — Little Rock, Arkansas, United States (enrolling)
- University of California Davis — Sacramento, California, United States (enrolling)
- Children's National Hospital — Washington D.C., District of Columbia, United States (enrolling)
- Emory University-Arthur M. Blank Hospital — Atlanta, Georgia, United States (enrolling)
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States (enrolling)
- Primary Children's Hospital — Salt Lake City, Utah, United States (enrolling)
- University of Washington Harborview — Seattle, Washington, United States (enrolling)
- University of Arizona — Tucson, Arizona, United States (enrolling)
- University of Mississippi Medical Center — Jackson, Mississippi, United States (enrolling)
- Washington University of St. Louis — St Louis, Missouri, United States (enrolling)
- University of New Mexico — Albuquerque, New Mexico, United States (enrolling)
- Wake Forest University Health Sciences — Wake Forest, North Carolina, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- Oregon Health and Science University — Portland, Oregon, United States (enrolling)
- Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States (enrolling)
- LeBonheur Children's Hospital — Memphis, Tennessee, United States (enrolling)
- Baylor College of Medicine — Houston, Texas, United States (enrolling)
- Children's Memorial Hermann Hospital — Houston, Texas, United States (enrolling)
- Emory University-Scottish Rite Hospital — Atlanta, Georgia, United States
- Tulane School of Medicine — New Orleans, Louisiana, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- The University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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