Propranolol in Primary Progressive Aphasia
Recruiting now · Early Phase 1 · Has a placebo group
Conditions studied: Aphasia, Primary Progressive
In brief
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
Key facts
- Study ID
- NCT06066710
- Run by
- University of Missouri-Columbia
- People needed
- 30
- Starts
- 2025-01-13
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-17
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1. Age: 50 and older
- 2. Primary Progressive Aphasia diagnosis
- 3. Native English speaker
You may not qualify if…
- 1. Unable to provide consent
- 2. Taking alpha 2 agonists (clonidine and guanfacine)
- 3. Other major psychological or neurological diagnosis
- 4. Major head trauma that contributed to their condition
- 5. Allergic reaction to adhesives
- 6. Uncorrected vision/hearing impairments
- 7. Diabetes
- 8. Reactive airway disease
- 9. Untreated hypothyroidism
- 10. Bradyarrhythmia
- 11. Unexplained syncope
- 12. Pregnancy (assessed verbally on the days of MR imaging)
- 13. Drugs that interact with propranolol, such as alpha 2 agonists
- 14. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.
Where it is running
- University of Missouri-Columbia — Columbia, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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