Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Myasthenia Gravis
Recruiting now · Not applicable
Conditions studied: Generalized Myasthenia Gravis
In brief
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on neuromuscular junction (NMJ) transmission and fatigability in adults with Generalized Myasthenia Gravis (gMG). The investigators will also test whether a relationship exists between NMJ transmission dysfunction and fatigability in gMG, which has long been presumed but never directly assessed. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered 2 times per week for 4 weeks. Long-term follow up is optional. The hypotheses are (a) that the WB-EMS exercise will improve fatigability and NMJ transmission, and (b) that NMJ transmission dysfunction is related to fatigability.
Key facts
- Study ID
- NCT06064695
- Run by
- University of Missouri-Columbia
- People needed
- 16
- Starts
- 2023-07-12
- Expected to finish
- 2025-08-01
- Last updated by the study team
- 2025-04-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- University of Kansas Clinical Research Center — Fairway, Kansas, United States (enrolling)
- NextGen Precision Health Building, Clinical and Translational Science Unit — Columbia, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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