A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight

In brief

The purpose of the study is to evaluate if a new study drug, NNC0487-0111, is safe and how it works in the participant's body, when given as injections under the skin

Key facts

Study ID

NCT06064006

Run by

Novo Nordisk A/S

People needed

125

Starts

2023-09-15

Expected to finish

2024-11-27

Last updated by the study team

2025-11-19

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female
• Aged 18-55 years (both inclusive) at the time of signing informed consent.
• Body Mass Index (BMI) between 27.0 and 39.9 kg/m\^2 (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator.
• Considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator.

You may not qualify if…

• Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol
• HbA1c equal to or greater than 6.5 % (48 mmol/mol) at screening
• Any laboratory safety parameters at screening outside the below laboratory ranges, see designated reference range documents for specific values:
• Vitamin D (25-hydroxycholecalciferol) below 12 ng/mL (30 nM) at screening
• Parathyroid hormone (PTH) outside normal range at screening
• Total calcium outside normal range at screening
• Amylase equal to or greater than 2 times upper limit of normal at screening
• Lipase equal to or greater than 2 times upper limit of normal at screening
• Calcitonin equal to or greater than 50 ng/L at screening

Where it is running

• ICON Early Phase Services, LLC — San Antonio, Texas, United States
• Novo Nordisk INvestigational Site — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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