Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)

Recruiting now · Not applicable

Conditions studied: Blood Pressure, Hydration, Vascular Disease Risk

In brief

Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium/day).

Key facts

Study ID: NCT06062017
Run by: Auburn University
People needed: 40
Starts: 2024-11-06
Expected to finish: 2027-07-01
Last updated by the study team: 2025-02-27

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Between the ages of 18-30 years
Resting blood pressure no higher than 150/90 mmHg
BMI below 35 kg/m2
Free of any metabolic disease (e.g., diabetes) kidney disease, pulmonary disorders (e.g., COPD), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer.

You may not qualify if…

Have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood.
Are currently pregnant or trying to become pregnant.
take any of the following medications that are contraindicated with potassium supplementation:
Renin-angiotensin-aldosterone system (RAAS) blockers: Candesartan , Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan
Non -steroidal anti-inflammatory medications: Aspirin, Ibuprofen, Naproxen
Non-selective beta-blockers: Pindolol, Penbutolol, Oxprenolol, Propranolol, Nadolol, Sotalol, Timolol, Tertatolol
Calcineurin inhibitors: Cyclosporine
Heparin (or other blood thinning medications)

Where it is running

Kinesiology Building — Auburn, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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