Effect of Timed-Restricted Eating on Metabolic Health

Recruiting now · Not applicable

Conditions studied: Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance

In brief

We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin resistance.

Key facts

Study ID

NCT06061042

Run by

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

People needed

30

Starts

2023-10-01

Expected to finish

2027-12-01

Last updated by the study team

2023-09-29

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to provide informed consent;
• BMI > 30kg/m\^2;
• Insulin resistance, as defined by fasting plasma insulin > 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose > 5.3 and < 7.0 mmol/L;
• Stable weight for 3 months prior to study inclusion
• For women, 1 year after last menstrual cycle

You may not qualify if…

• Use of any medication, except for those related to treatment of metabolic syndrome;
• Any medical condition interfering with study outcomes or design;
• History of any psychiatric disorder, including eating disorders;
• Performing shift work
• Performing intensive sports (>3 hours/week);
• Smoking;
• Drugs abuse or alcohol abuse (>3 units/day);
• Contraindication for MRI;
• Known lactose/gluten intolerance;
• Known soy, egg, milk or peanut allergy;
• Childhood onset of obesity

Where it is running

• Amsterdam UMC, location AMC — Amsterdam, North Holland, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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