Imaging Biomarkers for Myofascial Pain

Completed

Conditions studied: Myofascial Pain Syndrome, Healthy

In brief

Myofascial pain syndrome (MPS) is highly prevalent in the community. It is primarily diagnosed using patient self reports and physical examination, which lack reliability, sensitivity and specificity and does not provide insights into the abnormal biological and physiological processes in soft tissues. While a number of treatment methods are available to patients, there are currently no criteria to determine which treatments might be best for each patient's unique myofascial pain phenotype. To improve evidence-based management of myofascial pain, there is a critical need to develop quantitative measures that advance the understanding of the physiological processes in the underlying the soft tissues across the clinical continuum of MPS. The objective of this project is to develop a quantitative biomarker informed by the current understanding of underlying tissue-level mechanisms at the level of the "myofascial unit" (muscle, nerve, fascia, vasculature, lymphatics) that are likely to be involved in MPS.

Key facts

Study ID: NCT06060925
Run by: George Mason University
People needed: 96
Starts: 2023-01-01
Expected to finish: 2025-08-31
Last updated by the study team: 2026-02-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age 18 and older

You may not qualify if…

Diagnosis of fibromyalgia, chronic fatigue syndrome or chronic Lyme disease confirmed by physical exam
Diagnosis of cervical radiculopathy, neuropathy or neuriitis
History of head, neck, or shoulder girdle surgery
Atypical facial neuralgia
New medication or change in medication in past 6 months
Current throat or ear infection

Where it is running

George Mason University — Fairfax, Virginia, United States

Full record on ClinicalTrials.gov

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