PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.

Recruiting now · Phase 2

Conditions studied: TNBC - Triple-Negative Breast Cancer

In brief

This is a descriptive, prospective, single centre study. This study will assess PSMA expression via the uptake of radiolabelled PSMA-ligand using PET/CT imaging in mTNBC lesions pre-identified on 18F-FDG PET/CT in order to evaluate the feasibility of molecular radionuclide therapy in refractory mTNBC using the Lutetium-177 radiolabelled PSMA.

Key facts

Study ID

NCT06059469

Run by

Jules Bordet Institute

People needed

20

Starts

2022-05-30

Expected to finish

2025-12-01

Last updated by the study team

2025-07-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent in accordance with institutional guidelines and obtained prior to any study procedure
• Women with ≥ 18 years-old
• Eastern Cooperative Oncology Group Performance Status of 0 to 2
• Confirmed diagnosis of progressive metastatic TNBC and presenting measurable disease on 18F-FDG PET/CT (performed within 2 weeks) or Brain MRI in case of progressive brain metastases (performed within 4 weeks) prior to PSMA PET/CT.
• Radiolabelled PSMA PET/CT has to be performed before the next treatment line initiation

You may not qualify if…

• Pregnant or lactating patients
• Other active neoplastic disease
• Treatment by another molecule that is the object of investigation within 30 days
• Skin only metastatic disease
• Patients with a significant medical, neuro-psychiatric, or surgical condition, which, in the investigator's opinion, may interfere with completion of the study

Where it is running

• Institut Jules Bordet — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

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