Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Recruiting now

Conditions studied: Behavioral Variant of Frontotemporal Disorder (bvFTD), Phenocopy Frontotemporal Dementia (phFTD), Frontal Variant of Alzheimer Disease, Bipolar Disorder

In brief

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Key facts

Study ID

NCT06059313

Run by

Nantes University Hospital

People needed

120

Starts

2023-12-14

Expected to finish

2026-12-14

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
• Score for Mini-mental state examination ≥ 18
• Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset.
• Patient and caregiver consents (no opposition)

You may not qualify if…

• Patient with no caregiver
• Pregnant or breast feeding women

Where it is running

• CHU de Nantes — Nantes, France (enrolling)

Full record on ClinicalTrials.gov

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