Epileptogenic Network Visualisation With Advanced MRI

Recruiting now · Not applicable

Conditions studied: Drug Resistant Epilepsy

In brief

The goal of this clinical trial is to improve non-invasive identification of epileptogenic networks in drug-resistant epileptic patient. The investigators aim to compare epileptogenic network identification with stereo-EEG (used as glod standard) with the identification of the same network using advanced MRI (rs-fMRI, microstructural analysis of white matter, ...). The main goals are to: 1. Compare the accuracy of network identification. 2. Analyse the effect of the MRI sequences on candidates selection and target identification. Participants will already have been selected for stereoEEG and will undergo a supplementary MRI (about 1h) with the additional MRI sequences. Follow-up MRI are scheduled for patient undergoing a second, therapeutic epileptic surgery.

Key facts

Study ID

NCT06059157

Run by

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

People needed

80

Starts

2023-10-25

Expected to finish

2029-10-01

Last updated by the study team

2026-06-15

Who can join

Age: 3 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient suffering from drug-resistant epilepsy
• Patient already selected for SEEG implantation as part of their epileptic networks

You may not qualify if…

• Patient excluded from SEEG (pregnant women, children too young for the procedure, patient unable to undergo the procedure)
• Contra-indication for MRI

Where it is running

• Cliniques Universitaires St-Luc — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

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