The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Chronic Kidney Diseases

In brief

CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up.

Key facts

Study ID

NCT06058585

Run by

The George Institute

People needed

1000

Starts

2024-09-04

Expected to finish

2029-03-31

Last updated by the study team

2026-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Known chronic kidney disease from any cause (eGFR ≥25 mL/min/1.73m2)
• Currently receiving standard of care treatment according to treating physician
• Eligible for randomisation in at least one recruiting domain-specific appendix
• Participant and treating physician are willing and able to perform trial procedures

You may not qualify if…

• Planned to commence kidney replacement therapy or kidney transplant surgery in next 6 months
• Life expectancy less than 6 months

Where it is running

• The Canberra Hospital — Garran, Australian Capital Territory, Australia (enrolling)
• Nepean Blue Mountains Local Health District — Kingswood, New South Wales, Australia (enrolling)
• St George Hospital — Kogarah, New South Wales, Australia (enrolling)
• John Hunter Hospital — New Lambton Heights, New South Wales, Australia (enrolling)
• Westmead Hospital — Westmead, New South Wales, Australia (enrolling)
• Sunshine Coast Hospital and Health Service — Birtinya, Queensland, Australia (enrolling)
• Townsville University Hospital — Douglas, Queensland, Australia (enrolling)
• West Moreton Hospital & Health Service — Ipswich, Queensland, Australia (enrolling)
• Gold Coast Hospital and Health Service — Southport, Queensland, Australia (enrolling)
• Royal Adelaide — Adelaide, South Australia, Australia (enrolling)
• Lyell McEwin Hospital — Elizabeth Vale, South Australia, Australia (enrolling)
• Austin Health — Heidelberg, Victoria, Australia (enrolling)
• South Metropolitan Health Service, Fiona Stanley Hospital — Murdoch, Western Australia, Australia (enrolling)
• Gitam Institute of Medical Sciences and Research — Visakhapatnam, Andhra Pradesh, India (enrolling)
• Patna Medical College and Hospital — Patna, Bihar, India (enrolling)
• DKS Super Speciality Hospital, Raipur — Raipur, Chhattisgarh, India (enrolling)
• Mysore Medical College — Dehradun, Dehradun, India (enrolling)
• GCS Medical College, Hospital & Research Centre — Ahmedabad, Gujarat, India (enrolling)
• Father Muller Medical College Hospital — Mangaluru, Karnataka, India (enrolling)
• Dr Moopen's Medical College — Meppādi, Kerala, India (enrolling)
• CARE-CHL Hospital — Indore, Madhya Pradesh, India (enrolling)
• Medway Hospital — Chennai, Tamil Nadu, India (enrolling)
• Yashoda Hospital Hitec City — Hyderabad, Telangana, India (enrolling)
• Apollo Hospitals — Hyderabad, Telangana, India (enrolling)
• Charak Hospital and Research Centre — Lucknow, Uttar Pradesh, India (enrolling)

Full record on ClinicalTrials.gov

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