RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome
Recruiting now
Conditions studied: Coronary Syndrome
In brief
Identify circulating protein-coding (mRNAs) or non-coding (ncRNAs) transcripts (ACS\_signature) predictive of ventricular dysfunction in ACS patients undergoing PCI.
Key facts
- Study ID
- NCT06058182
- Run by
- IRCCS Policlinico S. Donato
- People needed
- 70
- Starts
- 2020-07-13
- Expected to finish
- 2027-01-30
- Last updated by the study team
- 2023-10-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 years
- Patients with ACS (first episode), defined according to the guidelines of the European Society of Cardiology (ESC) 2017
- Indication for percutaneous revascularization treatment
- Informed consent to study enrollment
You may not qualify if…
- Severe valve disease or other conditions requiring cardiac surgery
- Previous cardiac surgery including coronary artery bypass grafts
- Total chronic occlusions
- Patients with known hypersensitivity or contraindication to any of the following drugs:
- heparin
- aspirin,
- clopidogrel,
- ticlopidine,
- sirolimus,
- everolimus.
- Any contraindication to drug-eluting stent implantation (DES)
- Patients with a documented history of myocardial infarction;
- Left ventricular ejection fraction (LVEF) <30% before PCI
- Patients in cardiogenic shock
- Patients with advanced ST-segment elevation myocardial infarction (> 48 h from onset of symptoms/Q waves on electrocardiogram) or undergoing fibrinolysis;
- Patients with prior known cardiomyopathy with LVEF < 40%
- Patients with malignant neoplasm or systemic disease with quoad vitam prognosis less than 1 year;
- Patients with known active infectious diseases;
- Patients who are unable to express valid informed consent to the act of enlistment
- Pregnant women
Where it is running
- IRCCS Policlinico S. Donato, Milan, Italy — Milan, Milan, Italy (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.