Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

Completed · Phase 3 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

This randomized, double-blind, placebo-controlled, multicenter study will evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 35 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501).

Key facts

Study ID

NCT06058039

Run by

Neumora Therapeutics, Inc.

People needed

422

Starts

2023-12-21

Expected to finish

2026-06-11

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Neumora Investigator Site — Irvine, California, United States
• Neumora Investigator Site — Long Beach, California, United States
• Neumora Investigator Site — San Diego, California, United States
• Neumora Investigator Site — San Francisco, California, United States
• Neumora Investigator Site — New Haven, Connecticut, United States
• Neumora Investigator Site — Brandon, Florida, United States
• Neumora Investigator Site — Hialeah, Florida, United States
• Neumora Investigator Site — Hialeah, Florida, United States
• Neumora Investigator Site — Jacksonville, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator site — Miami, Florida, United States
• Neumora Investigator Site — Miami Beach, Florida, United States
• Neumora Investigator site — Miami Springs, Florida, United States
• Neumora Investigator Site — Palm Bay, Florida, United States
• Neumora Investigator Site — Pembroke Pines, Florida, United States
• Neumora Investigator Site — Pompano Beach, Florida, United States
• Neumora Investigator Site — Saint Augustine, Florida, United States
• Neumora Investigator Site — Atlanta, Georgia, United States
• Neumora Investigator Site — Decatur, Georgia, United States
• Neumora Investigator Site — Savannah, Georgia, United States
• Neumora Investigator Site — Springfield, Massachusetts, United States
• Neumora Investigator Site — St Louis, Missouri, United States
• Neumora Investigator Site — Omaha, Nebraska, United States
• Neumora Investigator Site — Cerritos, California, United States

Full record on ClinicalTrials.gov

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