Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

Completed · Phase 3 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501).

Key facts

Study ID

NCT06058013

Run by

Neumora Therapeutics, Inc.

People needed

430

Starts

2023-12-20

Expected to finish

2026-06-17

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Neumora Investigator Site — Garden Grove, California, United States
• Neumora Investigator Site — Los Alamitos, California, United States
• Neumora Investigator Site — Newport Beach, California, United States
• Neumora Investigator Site — Orange, California, United States
• Neumora Investigator Site — Santa Ana, California, United States
• Neumora Investigator Site — Norwalk, Connecticut, United States
• Neumora Investigator Site — Bradenton, Florida, United States
• Neumora Investigator Site — Hollywood, Florida, United States
• Neumora Investigator Site — Homestead, Florida, United States
• Neumora Investigator Site — Lauderhill, Florida, United States
• Neumora Investigator Site — Maitland, Florida, United States
• Neumora Investigator Sites — Miami, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator Site — Miami, Florida, United States
• Neumora Investigator Site — Miami Lakes, Florida, United States
• Neumora Investigator Site — Miami Lakes, Florida, United States
• Neumora Investigator Site — Orlando, Florida, United States
• Neumora Investigator Site — Orlando, Florida, United States
• Neumora Investigator Site — Orlando, Florida, United States
• Neumora Investigator Site — Pinellas Park, Florida, United States
• Neumora Investigator Site — Pompano Beach, Florida, United States
• Neumora Investigator Site — Tampa, Florida, United States
• Neumora Investigator Site — Encino, California, United States

Full record on ClinicalTrials.gov

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