Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
Recruiting now · Not applicable
Conditions studied: Bronchiolitis
In brief
This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy (including intubation) when compared to using a standard mode of non-invasive ventilation. Neurally-Adjusted Ventilatory Assistance (NAVA) has been shown to result in greater synchrony then the standard mode of non-invasive ventilation. The study team hypothesizes that this improved synchrony can result in important clinical improvements when NAVA is used to treat children with bronchiolitis.
Key facts
- Study ID
- NCT06053684
- Run by
- Montefiore Medical Center
- People needed
- 130
- Starts
- 2023-12-18
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2025-09-05
Who can join
Age: any, up to 2. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients under the age of two years old with a diagnosis of bronchiolitis presenting to the pediatric ICU
- Patient's provider believes there is equipoise between the use of NAVA or conventional non-invasive ventilation for the patient
You may not qualify if…
- Patients unable to utilize a nasogastric tube
- Patients with a diagnosis of chronic lung disease, cyanotic heart lesions, or congestive heart failure
- Patients with hypotonia
- Patients likely to require imminent intubation: >0.60 Fraction of Inspired Oxygen (FiO2); Carbon Dioxide (CO2) > 60, frequent apneas, clinician determines patient unlikely to tolerate non-invasive modality)
- Patients with hemodynamic instability, defined as the need for vasoactive medication
Where it is running
- Children's Hospital at Montefiore — The Bronx, New York, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.