Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization

Recruiting now · Not applicable

Conditions studied: Massage Therapy, Muscular Atrophy

In brief

The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry. Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow. Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.

Key facts

Study ID

NCT06053229

Run by

Brigham Young University

People needed

36

Starts

2023-03-01

Expected to finish

2025-07-31

Last updated by the study team

2024-08-13

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals.
• Stable levels of physical activity for at least 6 months
• No history of lower extremity injury that would preclude their ability to perform knee extension exercise

You may not qualify if…

• Cigarette or marijuana smoker
• Pregnant or planning to become pregnant within next month
• Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment)
• Taking prescribed medications (e.g. blood pressure medication) or anti-depressants
• Habitual use of any type of massage or vibration on their thigh
• Note that subjects who are mentally unable to understand the consenting process and provide informed consent will not be included in this study.

Where it is running

• Brigham Young University — Provo, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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