Assessing Optimal XRB Initiation Points in Jail
Recruiting now · Phase 4
Conditions studied: Opioid Use Disorder
In brief
This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial detainees will be randomized at admission on a 1:1 basis to be inducted onto extended-release buprenorphine (XRB) at the time of admission (experimental condition) or remain in SLB (E-TAU; all participants will also receive naloxone). The two approaches will be compared with regard to (1) the percentage of participants released from jail with at least 7 days of buprenorphine in their system, (2) percentage of participants continuing MOUD treatment in the community, and (3) infractions related to buprenorphine diversion.
Key facts
- Study ID
- NCT06051890
- Run by
- NYU Langone Health
- People needed
- 50
- Starts
- 2025-06-02
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-08-07
Who can join
Age: any. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Incarcerated men able to provide written informed consent in English.*
- Unsentenced.
- Entering the facility with a prescription for SLB and receiving SLB for at least the previous 3 days.
- Minimum anticipated jail stay is 4 days.
- Willing to accept being randomized to the experimental condition (i.e., transitioning to XRB while incarcerated).
You may not qualify if…
- Sentenced.
- Allergy, hypersensitivity or medical contraindication to either medication.
- Chronic pain requiring opioid pain management or other contraindicated medications.
Where it is running
- Tufts University Health Sciences — Boston, Massachusetts, United States (enrolling)
- Baystate Health — Springfield, Massachusetts, United States (enrolling)
- Middlesex County House of Corrections — New Brunswick, New Jersey, United States (enrolling)
- NYU Langone Health - 180 Madison Ave — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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