Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement

Recruiting now · Not applicable

Conditions studied: Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome

In brief

Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes). However, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters. To address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes

Key facts

Study ID

NCT06051292

Run by

Dr. Behcet Uz Children's Hospital

People needed

27

Starts

2023-09-18

Expected to finish

2025-12-30

Last updated by the study team

2025-03-20

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pediatric patients between 1 months and 18 years
• Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours
• Informed consent was signed by next of kin
• Requiring esophageal catheter application

You may not qualify if…

• Patients eligible for extubation or modification of ventilation settings within the upcoming 2 hours
• Patient included in another interventional study in the last 30 days
• Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies
• Patient included in another interventional research study under consent
• Patient already enrolled in the present study in a previous episode of acute respiratory failure

Where it is running

• Aydin Obstetric and pediatrics Hospital — Aydin, Turkey (Türkiye) (enrolling)
• Erzurum Regional Research and Training Hospital — Erzurum, Turkey (Türkiye) (enrolling)
• Cam Sakura Research and Training Hospital — Istanbul, Turkey (Türkiye) (enrolling)
• The Health Sciences University Izmir Behçet Uz Child Health and Diseases Research and Training Hospital — Izmir, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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