CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations

Recruiting now · Not applicable

Conditions studied: Cocaine Use Disorder

In brief

This research focuses on behavioral sensitization (BS) a specific behavioural disturbance in crack-cocaine addiction. The primary objective is to observe whether BS can be demonstrated in an ecological setting in crack dependent users by continuous actimetry for 3 weeks. It is planned to include 20 persons with a current crack-cocaine addiction with a preferential use of rapid administration route (intravenous or smoke), in a care institution: Fernand Widal Hospital. In the proposed research, the investigators will assess the movements of crack-cocaine dependent users in relation to consumption. They will have to wear continuously for 3 weeks an actimeter. They will also have 3 blood tests trying to identify biomarkers of BS.

Key facts

Study ID

NCT06050304

Run by

Assistance Publique - Hôpitaux de Paris

People needed

20

Starts

2025-03-04

Expected to finish

2026-03-04

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 18 years
• Have a current crack-cocaine use disorder defined as Severe Intensity Use Disorder (6 or more DSM5 criteria), AND preferential use of rapid administration route (intravenous or smoked)
• Self-identified male or female (n=10 males, n=10 females)
• Negative pregnancy test for females and use of effective contraception
• Be affiliated with a social security plan (or PUMA or CSS or AME)
• Sign an informed consent and commit to a 3-week follow-up in the study
• Have a weight greater than 40 kg

You may not qualify if…

• • Patient with a psychiatric disorder or symptoms that are not currently stabilized
• Patient who is a minor or under protective supervision (curatorship or guardianship)
• Patient in care at the request of a judicial authority (therapeutic injunction, classification with orientation)
• Pregnant or breastfeeding women
• Patients who do not speak French or English sufficiently
• Patients weighing less than 40 kg

Where it is running

• Centre 001_Hôpital Fernand Widal — Paris, France (enrolling)
• Hôpital Fernand Widal — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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