Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Gorlin Syndrome

In brief

The aim of this clinical study is to find out how well Patidegib Gel 2% works in preventing new basal cell carcinomas (BCCs) developing on the face of adults with Gorlin syndrome, and how safe Patidegib Gel 2% is to use. People who take part will apply either Patidegib Gel 2% or a Vehicle Gel (with no active drug substance) to their face twice a day for a year (12 months). The number of new BCCs on the face will be compared between those who used Patidegib Gel 2% or Vehicle Gel after 12 months.

Key facts

Study ID

NCT06050122

Run by

Sol-Gel Technologies, Ltd.

People needed

140

Starts

2024-03-17

Expected to finish

2026-08-01

Last updated by the study team

2025-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Northwest Arkansas Clinical Trials Center — Rogers, Arkansas, United States
• Center for Dermatology Clinical Research — Fremont, California, United States
• University of California Los Angeles (UCLA) - Center for Inflammatory Bowel Diseases - Westwood Location — Los Angeles, California, United States
• The Dermatology Center of Newport — Newport Beach, California, United States
• Stanford University - Lucille Packard's Children's Hospital — Redwood City, California, United States
• Yale University — New Haven, Connecticut, United States
• Dermatology Associates of Tallahassee — Tallahassee, Florida, United States
• University of South Florida Health — Tampa, Florida, United States
• The University of Chicago Medicine — Chicago, Illinois, United States
• The Johns Hopkins Hospital — Baltimore, Maryland, United States
• University of Michigan Health - Michigan Medicine - University Hospital — Ann Arbor, Michigan, United States
• Minnesota Clinical Study Center — New Brighton, Minnesota, United States
• MediSearch Clinical Trials — Saint Joseph, Missouri, United States
• Schweiger Dermatology P.C. — Verona, New Jersey, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Duke University Health System — Durham, North Carolina, United States
• Apex Clinical Research Center — Canton, Ohio, United States
• Cleveland Clinic - Main Campus — Cleveland, Ohio, United States
• Apex Clinical Research Center — Mayfield Heights, Ohio, United States
• SSM Health Dermatology — Oklahoma City, Oklahoma, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Penn State Hershey Medical Center — Hershey, Pennsylvania, United States
• North Texas Center for Clinical Research — Frisco, Texas, United States
• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
• Hopital Avicenne — Bobigny, France

Full record on ClinicalTrials.gov

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