Circulating Tumour Cells Characterization in Breast Cancer Patients

Recruiting now

Conditions studied: Breast Cancer

In brief

In the current scenario, a reliable liquid biopsy method for predicting outcomes in solid tumors, especially among breast cancer patients, is lacking. Circulating Tumor Cells (CTCs) serve as crucial indicators of metastasis, and their early detection could significantly enhance patient stratification and facilitate the customization of personalized treatments. However, detecting CTCs in breast cancer patients presents complexities due to their substantial phenotypic heterogeneity and typically low concentration. Numerous approaches have been developed for CTC detection. Nonetheless, the currently available technologies remain intricate, time-consuming, and costly. The BioCellPhe Project is dedicated to the development of a novel device capable of isolating and characterizing individual CTCs. This innovative device relies on the identification of specific cell membrane proteins with remarkable precision, achieved through the application of novel orthogonal techniques. On one hand, engineered bacteria are utilized to precisely bind to membrane proteins of interest on CTCs. On the other hand, Surface Enhanced Raman Spectroscopy (SERS) is employed for the detection of individual molecules. Specifically, the BioCellPhe Project focuses on comprehensively studying CTCs in breast cancer patients, encompassing both metastatic and non-metastatic cases.

Key facts

Study ID

NCT06048835

Run by

Istituti Clinici Scientifici Maugeri SpA

People needed

80

Starts

2022-12-01

Expected to finish

2028-12-31

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older, up to 90. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• female patients with diagnosis of metastatic breast cancer, confirmed by clinical practice staging exams.
• female patients with biopsy-confirmed diagnosis of early-breast cancer candidate for primary surgery after multidisciplinary evaluation.
• patients not affected by any neoplastic disease.

You may not qualify if…

• Diagnosis of any neoplastic disease

Where it is running

• Istituti Clinici Scientifici Maugeri SpA — Pavia, Lombardy, Italy (enrolling)

Full record on ClinicalTrials.gov

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