A Study of Contralateral Limb Block

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Limb Pain, Phantom

In brief

This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.

Key facts

Study ID

NCT06045936

Run by

Mayo Clinic

People needed

20

Starts

2024-06-18

Expected to finish

2026-12-01

Last updated by the study team

2026-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lower extremity amputation performed more than 12 months before study enrollment
• PLP/RLP in affected amputated limb > 4 on NRS26
• Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis)
• Willingness to undergo image guided diagnostic nerve block

You may not qualify if…

• Refusal / inability to participate or provide consent
• Contraindications to diagnostic nerve block
• Non-neurogenic source of PLP/RLP
• Current opioid use > 50 morphine milligram equivalents per day
• Any interventional pain treatment in the residual limb within the last 30 days
• Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism)
• Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment

Where it is running

• Mayo Clinic Health System - Mankato — Mankato, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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