Sevoflurane's Effect on Neurocognition Study

Completed · Early Phase 1

Conditions studied: Anesthesia, Pain, Amnesia

In brief

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Key facts

Study ID

NCT06044740

Run by

Keith M Vogt

People needed

42

Starts

2024-01-17

Expected to finish

2026-01-30

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 59. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults, age 18-59, who are native English speakers with at least a high school education
• have normal hearing and memory
• be of normal body-weight
• be generally healthy (free from significant chronic disease)
• have none of the specific exclusion criteria
• have a valid email address and valid phone number throughout the study
• anticipate ability to participate in all visits required for the phase of the study in which they are enrolled

You may not qualify if…

• being pregnant or attempting to conceive
• having a body mass index (BMI) > 35
• having significant memory impairment or hearing loss
• having sleep apnea
• having chronic pain or frequently taking pain medication (including tramadol)
• having any severe or poorly-controlled medical problem (hypertension, diabetes)
• having neurologic or psychiatric disease, including anxiety, and depression
• having significant cardiac valvular disease or cardiomyopathy
• having a history of abnormal heartbeats (cardiac conduction abnormality or arrhythmia)
• having a history of seizures or convulsions
• having a history of liver disease
• having a history of asthma or other significant pulmonary disease
• having a history of malignant hyperthermia, muscular dystrophy, central core disease, or hyperkalemia
• being claustrophobic
• have metal implants or non-removable metal piercings
• having a history of adverse reaction to anesthetics
• daily alcohol or heavy alcohol use; history of alcohol abuse
• current daily smoker
• regular or recent marijuana use (including prescribed/medical marijuana)
• illicit drug use
• regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids
• current use of selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs) and some other specific drugs phenytoin, carbamazepine, and rifampin
• history of QT prolongation
• hypersensitivity or allergic reaction to ondansetron (Zofran)

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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