A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
Enrolling by invitation · Phase 3
Conditions studied: Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
In brief
In this study, researchers will learn more about a study drug called BIIB059 (litifilimab) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue. The study will enroll only those participants who have completed treatment with litifilimab in the parent study, 230LE301. The main objective of the study is to learn more about the long-term safety of litifilimab. The main question researchers want to answer is: * How many participants have adverse events and serious adverse events after taking litifilimab? Adverse events are health problems that may or may not be caused by the study drug. Researchers will also learn more about the effect of litifilimab on CLE. They will do this by measuring the symptoms of CLE over time using a variety of scoring tools. These include the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), the Cutaneous Lupus Activity of Investigator's Global Assessment-Revised (CLA-IGA-R), and the SELENA-SLEDAI Flare Index (SFI). Researchers will look at how litifilimab and CLE affect the quality of life of participants using a group of questionnaires. They will also look at how litifilimab affects laboratory tests and how participants' immune systems respond to litifilimab. The study will be done as follows: * The last visit of parent study 230LE301 will be the first visit of study 230LE305. * All participants will receive litifilimab as an injection under the skin once every 4 weeks. Both researchers and participants will know the dose and identity of the study drug. * Globally, the treatment period will last up to 208 weeks, or 4 years. Participants will have up to 53 study visits during this time.
Key facts
- Study ID
- NCT06044337
- Run by
- Biogen
- People needed
- 306
- Starts
- 2023-10-03
- Expected to finish
- 2029-12-11
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Arthritis & Rheumatology Research, PLLC — Phoenix, Arizona, United States
- Dermatology Research Associates — Los Angeles, California, United States
- Inland Rheumatology Clinical Trials, Inc. — Upland, California, United States
- David Fivenson, MD, Dermatology, PLLC — Ann Arbor, Michigan, United States
- Revival Research Institute, LLC — Troy, Michigan, United States
- Saint Louis University — St Louis, Missouri, United States
- Thurston Arthritis Research Center — Chapel Hill, North Carolina, United States
- Duke Dermatology South Durham — Durham, North Carolina, United States
- University of Cincinnati Health Physicians Office Dermatology — Cincinnati, Ohio, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
- Precision Comprehensive Clinical Research Solutions — Grapevine, Texas, United States
- Instituto CAICI — Rosario, Santa Fe Province, Argentina
- Investigaciones Clinicas Tucuman — San Miguel de Tucumán, Tucumán Province, Argentina
- Centro de Investigaciones Medicas Tucuman — San Miguel de Tucumán, Tucumán Province, Argentina
- APRILLUS Asistencia e Investigacion — Buenos Aires, Argentina
- Clínica SER da Bahia — Salvador, Estado de Bahia, Brazil
- L2IP - Instituto de Pesquisas Clínicas Ltda. — Brasília, Federal District, Brazil
- IPC MT Instituto de Pesquisas Clinicas do Mato Grosso — Santo Ângelo, Mato Grosso, Brazil
- CMiP - Centro Mineiro de Pesquisa — Juiz de Fora, Minas Gerais, Brazil
- Hospital de Clínicas de Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil
- Nucleo de Pesquisa Clinica do Rio Grande do Sul — Porto Alegre, Rio Grande do Sul, Brazil
- LMK Serviços Médicos S/S Ltda — Porto Alegre, Rio Grande do Sul, Brazil
- CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos — São Paulo, São Paulo, Brazil
- University of Alabama at Birmingham - (UAB) — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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