Brain and Stress Study

Completed · Phase 4 · Has a placebo group

Conditions studied: Stress, Psychological, Motivation

In brief

Motivational deficits such as anhedonia are core to several psychiatric disorders and underlie significant functional impairment. This double-blind, placebo-controlled crossover trial of minocycline, an anti-\[neuro\]inflammatory agent, examines links between chronic stress and responses to a reward-related motivation task. It will evaluate the effects of pharmacologically attenuating neuroinflammation on behavioral responses to a reward-related motivation task in individuals experiencing unemployment. Understanding the effects of neuroinflammation on reward function among individuals experiencing chronic stress represents a critical first step in identifying novel neuroimmune targets for future clinical trials.

Key facts

Study ID

NCT06044090

Run by

University of North Carolina, Chapel Hill

People needed

10

Starts

2022-09-12

Expected to finish

2023-12-19

Last updated by the study team

2024-12-18

Who can join

Age: 25 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 25-60 years old
• Unemployed (working less than 20 hours per week)
• Have been unemployed for at least 6 months
• Seeking employment
• Having trouble finding a job (i.e., actively seeking and applying for jobs but not successful in landing a job)
• Reports greater than 5 points on Job Stress Items
• Regular access to a mobile phone

You may not qualify if…

• Self-reported physical illnesses: diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus
• neurological conditions (e.g., Traumatic Brain Injury, stroke)
• pregnant (as measured by urine pregnancy screen) or breastfeeding
• current use of psychotropic medications
• Current regular recreational drug or alcohol use (i.e., 4 or more times per week)
• chronic diseases that significantly impact inflammatory markers (e.g., cancer)
• known allergies or hypersensitivities to tetracycline antibiotics, aspirin or other NSAIDs
• current antibiotic use
• regular use of steroidal or non-steroidal anti-inflammatory medications (i.e., 2 or more times a week)

Where it is running

• Howell Hall — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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