Revitalization of Traumatized Immature Permanent Teeth

Recruiting now

Conditions studied: Apical Periodontitis, Trauma

In brief

This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining/regaining pulp sensitivity and survival, than teeth with (a)symptomatic apical periodontitis.

Key facts

Study ID

NCT06043453

Run by

Universitaire Ziekenhuizen KU Leuven

People needed

72

Starts

2023-10-01

Expected to finish

2030-09-01

Last updated by the study team

2024-07-01

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Provision of Informed Consent
• Female and male patients
• Age range: 6-18 years
• "Healthy": ASA I and II
• Permanent immature tooth (Cvek stage of root maturation ≤ 2) requiring revitalization
• Etiological factor: (a)symptomatic apical periodontitis post dental trauma or irreversible pulpitis post dental trauma

You may not qualify if…

• Unlikely to be able to comply with the study procedures, as judged by the investigator
• Patients older than 18 years and younger than 6
• Deciduous teeth
• Cvek root maturation stage > 2: permanent immature tooth that can be treated by conventional root canal treatment or apexification
• Known or suspected current malignancy
• History of chemotherapy within 5 years prior to study
• History of radiation in the head and neck region
• History of other metabolic bone diseases
• Bleeding disorders
• Involvement in the planning and conduct of the study

Where it is running

• Ghent University — Ghent, Belgium (enrolling)

Full record on ClinicalTrials.gov

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