DIALYSIS-TIR Study
Running, not enrolling · Phase 4 · Has a placebo group
Conditions studied: Type 2 Diabetes, End Stage Renal Disease on Dialysis
In brief
This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide to people taking "dummy" medicine. The treatment participants get will be decided randomly. Participants will need to inject the study medication once a week. The study will last for 1 year and a month. Participants will be asked to wear a sensor that measures blood sugar levels for a period of 10 days at five different time points during the study.
Key facts
- Study ID
- NCT06042153
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 43
- Starts
- 2023-12-05
- Expected to finish
- 2028-09-01
- Last updated by the study team
- 2026-01-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ability to provide informed consent before any trial-related activities. Trial-related activities are any procedures that are carried out as a part of trial, including activities to determine suitability for the trial.
- Male or female Adults (age > 18 years at the time of signing the consent)
- Type 2 diabetes mellitus diagnosed > 6 months prior to screening
- On current chronic treatment with Hemodialysis or Peritoneal dialysis for > 6 months prior to screening
- Current treatment with any glucose lowering pharmacotherapy, at a stable dose for at least 30 days. DPP-4 Inhibitors will be allowed at study entry and will be stopped at randomization.
- Minimum of 80% valid data on the 10-day Continuous Glucose Monitor download
- Time in Range 15 to 60%
You may not qualify if…
- BMI < 23 kg/m2 at screening
- Current (within the past 90 days of screening) use of any GLP-1 RA
- Personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia type 2
- Known or suspected hypersensitivity to GLP-1 RA (trial medication(s), excipients, or related products)
- Pregnant, breast-feeding or the intention of becoming pregnant, or not using effective contraceptive measures
- Active weight loss, defined as weight loss of >5% of body weight in the past 3 months
- Current participation in other interventional trials or last dose of any investigational product within 4 half- lives at the time of randomization
- Any medical condition which in the judgement of the investigator precludes safe participation in the trial (includes, but not limited to active neoplasm, severe heart failure, recent cardiovascular event, severe frailty, planned cardiac or vascular surgeries on the day of screening etc)
- If weight loss is not desired by the participant, or if the provider or investigator considers intentional weight loss to be detrimental to the health of the participant
- Other or secondary forms of diabetes (like type 1 diabetes, pancreatogenic diabetes mellitus, MODY, LADA, drug induced, etc.)
- Current diagnosis of gastroparesis or enteropathywhich in the opinion of investigator precludes safe treatment with GLP-1 RA.
- Hypoglycaemia unawareness, or history of frequent or severe hypoglycaemia (in the opinion of the investigator)
- Personal history of chronic pancreatitis, or acute pancreatitis within 180 days of screening
- Known current uncontrolled or unstable retinopathy (by medical history)
Where it is running
- University of North Carolina — Chapel Hill, North Carolina, United States
- Davita UT Southwestern - Oak Cliff — Dallas, Texas, United States
- DaVita UT Southwestern - East Dallas — Dallas, Texas, United States
- DaVita UT Southwestern - Preston — Dallas, Texas, United States
- DaVita UT Southwestern - Irving — Irving, Texas, United States
Full record on ClinicalTrials.gov
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