International Registry of Congenital Portosystemic Shunt (IRCPSS)
Enrolling by invitation
Conditions studied: Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
In brief
Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications. CPSS is venous anomaly in which blood coming from the intestines only partially passes through the liver. This leads to the accumulation of potentially toxic factors that cause systemic effects. Complications vary among the individuals, and currently, it is challenging to predict which individuals will develop severe complications. The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up and biological information from participants around the world who suffer from Congenital Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to enhance our understanding of the prevalence, natural history, individual risks, and physiopathology of the disease through the IRCPSS registry.
Key facts
- Study ID
- NCT06041906
- Run by
- Prof. Valérie Mc Lin
- People needed
- 500
- Starts
- 2018-04-26
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-06-18
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Individual with CPSS
You may not qualify if…
- Secondary shunt without evidence of congenital shunt
Where it is running
- Yale University School of Medicine — New Haven, Connecticut, United States
- Lurie Children's Hospital — Chicago, Illinois, United States
- Royal Children's Hospital Melbourne — Parkville, Victoria, Australia
- Universitary Clinics Saint-Luc, UCL — Brussels, Belgium
- The Hospital for Sick Children — Toronto, Ontario, Canada
- Beaujon University Hospital — Clichy, France
- Hôpital Bicêtre-Hôpitaux Universitaires Paris-Sud- Assistance Publique Hôpitaux de Paris. — Le Kremlin-Bicêtre, France
- Hôpital Necker — Paris, France
- Hannover Medical School — Hanover, Germany
- Haunersche Kinderklinik - LMU Munich — Munich, Germany
- University of Tuebingen — Tübingen, Germany
- First Department of Pediatrics, Semmelweis University — Budapest, Hungary
- Amrita institute of Medical Sciences — Kochi, Kerala, India
- Department of Pediatric Hepatology Institute of Liver and Biliary Sciences — New Delhi, India
- Schneider Children's Medical Center of Israel — Petach Tikvah, Israel
- Papa Giovanni XXIII Hospital — Bergamo, Italy
- Children's Hospital Santobono — Naples, Italy
- Istituto di Ricovero e Cura a Carattere Scientifico (ISMETT) — Palermo, Italy
- National Center for Child Health and Development — Tokyo, Japan
- Academic Medical Centre — Amsterdam, Netherlands
- University Medical Center Groningen — Groningen, Netherlands
- Hospital Clínic de Barcelona — Barcelona, Spain
- Hôpitaux Universitaires de Geneve (HUG) — Geneva, Canton of Geneva, Switzerland
- Gazi University, Faculty of Medicine — Yenimahalle, Ankara, Turkey (Türkiye)
- Birmingham Children's Hospital — Birmingham, United Kingdom
Full record on ClinicalTrials.gov
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