Exercise Training on Brain Insulin Responsiveness
Recruiting now · Not applicable
Conditions studied: Insulin Resistance, Obesity
In brief
The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.
Key facts
- Study ID
- NCT06039787
- Run by
- University Hospital Tuebingen
- People needed
- 40
- Starts
- 2023-10-20
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2023-11-08
Who can join
Age: 20 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BMI between ≥ 19.5 to 39 kg/m2-
- Less than 150 min/week for moderate-intensity physical activity
- Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults)
- Written consent to participate in the study
- Written consent to be informed about incidental findings
You may not qualify if…
- Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke
- Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, …)
- Insufficient knowledge of the German language
- Persons who cannot legally give consent
- Pregnancy or lactation
- History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures and migraines)
- Taking psychotropic drugs
- Taking medications that influence glucose metabolism
- Regular use of analgesic drugs
- Taking anticoagulant agents
- Previous bariatric surgery
- Acute infection within the last 4 weeks
- Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
- Other diseases that in the opinion of the investigator may jeopardize the success of the study or indicate a risk to the volunteer
- Current participation in a lifestyle intervention study or a pharmaceutical study
- Metal implants which cannot be removed as pacemakers, artificial heart valve, electrical devices as insulin pumps, large tattoos, retainer over more than 4 teeth, contraceptive coil, implanted magnetic metal parts as screws or plates after a surgery
- Persons with claustrophobia
- Temperature-sensitive person
- Persons with tinnitus or increased sensitivity to loud sounds
Where it is running
- University Clinic Tübingen, Department of Internal Medicine IV — Tübingen, Germany (enrolling)
Full record on ClinicalTrials.gov
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