Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB
Withdrawn before enrolling · Not applicable
Conditions studied: Tooth Extraction, Immediate Implant Placement
In brief
The goal of this study is to test a volume-stable collagen matrix in combination with recombinant human platelet-derived growth factor-BB, specifically in patients who have an immediate implant placement for teeth #5-#12. The main question this study aims to answer is does the recombinant human platelet-derived growth factor-BB accelerate the formation of blood vessels and augment tissue volume around the immediate implant. Participants will be asked to undergo immediate implant placement using volume-stable collagen matrix in combination with recombinant human platelet-derived growth factor-BB, as well as attend 11 study visits over the course of 1.25 years.
Key facts
- Study ID
- NCT06038695
- Run by
- I-Ching Wang
- People needed
- 0
- Starts
- 2025-05-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2024-06-18
Who can join
Age: 18 and older, up to 95. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-95
- Has a single hopeless tooth in the maxillary esthetic zone (i.e., first premolar to first premolar, tooth #5-tooth #13)
- Adequate oral hygiene (i.e., full-mouth bleeding score (FMBS) and full mouth plaque score (FMPS) of less than 25%)
- Adequate tooth space to support an immediate implant placement (i.e., adequate mesiodistal space of greater than or equal to 6 mm and interocclusal space to support a non-occluding provisionalization).
- Postextraction vertical bone defect of the buccal socket wall was less than or equal to 3mm
You may not qualify if…
- patients taking long-term (more than 3 months) medications affecting bone metabolism
- generalized untreated periodontitis with greater than of 30% of sites with greater than 5mm pocket depths and bleeding upon probing with a dental probe
- medical contraindications for having a surgical procedure (i.e., ASA Status of III, patient with a severe systemic disease that is not life-threatening; ASA Status of IV, a patient with a severe systemic disease that is a constant threat to life).
- history of radiotherapy in the head and neck region
- heavy smoker (greater than 10 cigarettes per day)
- pregnancy
- gingival recession before extraction in relation to the contralateral tooth
Where it is running
- University of Iowa College of Dentistry and Dental Clinics — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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