LATe Cerclage in High-risk Pregnancies (LATCH)

Recruiting now · Not applicable

Conditions studied: Premature Birth

In brief

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

Key facts

Study ID

NCT06036446

Run by

Thomas Jefferson University

People needed

329

Starts

2023-11-10

Expected to finish

2029-02-01

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 18-50 years old, pregnant, assigned female at birth
• Singleton pregnancy
• TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation

You may not qualify if…

• Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed >14 weeks, or cotwin pregnancy loss diagnosed >14 weeks
• Cerclage in situ
• Preterm labor, defined as painful regular uterine contractions and change in cervical dilation
• PPROM
• Active vaginal bleeding
• Suspected intraamniotic infection
• Major fetal structural abnormality or chromosomal disorder
• Placenta previa or accreta
• Other contraindication to cerclage placement
• Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone

Where it is running

• Atrium Health Carolinas Medical Center — Charlotte, North Carolina, United States (enrolling)
• Thomas Jefferson University — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.