Remote Ischemic Conditioning in Aneurysmal SAH
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
In brief
The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage. The main question it aims to answer is whether RIC can improve long-term recovery in participants with aneurysmal subarachnoid hemorrhage. Researchers will compare levels of functional independence in participants in the RIC-group to participants in the sham-group.
Key facts
- Study ID
- NCT06032533
- Run by
- Aarhus University Hospital
- People needed
- 100
- Starts
- 2023-09-09
- Expected to finish
- 2027-11-30
- Last updated by the study team
- 2025-10-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA)
- Aneurysmal subarachnoid hemorrhage symptom-onset ≤ 3 days
- Aneurysm protected by clipping or coiling
- Independent in daily living before symptom onset (mRS ≤ 2)
You may not qualify if…
- Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm
- Symptomatic vasospasm at the time of enrollment
- Previous cerebral lesion e.g. symptomatic cerebral infarction (>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications).
- History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination
- History of deep vein thrombosis or signs of deep vein thrombosis on physical examination
- Kidney involvement or prior kidney disease with an estimated glomerular filtration rate (eGFR) below safe levels for contrast infusion in relation to CT-perfusion.
- Pregnancy (Women of child-bearing age will have serum-Humane Choriogonadotropine taken prior to final inclusion. If pregnancy cannot be ruled out,the patient can't be included. Women with a safe birth control method will be encouraged to use this method during the entire period of active treatment.)
- Concomitant other acute life-threatening medical or surgical condition
Where it is running
- Department of Neurosurgery, Aarhus University Hospital — Aarhus N, Danmark, Denmark (enrolling)
Full record on ClinicalTrials.gov
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