Timing of Endoscopy in Cirrhotic Patients with Acute Variceal Bleeding
Recruiting now · Not applicable
Conditions studied: Acute Upper Gastrointestinal Bleeding, Acute Variceal Bleeding
In brief
Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in patients with liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of timing of endoscopy on the outcomes of cirrhotic patients with AVB.
Key facts
- Study ID
- NCT06031402
- Run by
- General Hospital of Shenyang Military Region
- People needed
- 368
- Starts
- 2024-09-04
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-02-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients with AUGIB which is highly suspected to be caused by gastroesophageal variceal rupture;
- patients with a diagnosis of liver cirrhosis based on imaging and pathology;
- patients and/or their relatives who sign informed consents;
- patients' age ≥18 years.
You may not qualify if…
- patients who have undergone endoscopy at other hospitals before admissions;
- patients' hemodynamics are unstable after resuscitation;
- patients with severe cardiovascular or cerebrovascular diseases or renal injury;
- patients who have taken anticoagulants or antiplatelet drugs within 2 weeks before admissions, or are diagnosed with severe hematological diseases;
- patients with human immunodeficiency virus or other acquired or congenital immune deficiency diseases;
- patients with mental illness;
- pregnancy.
Where it is running
- Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area) — Shenyang, Liaoning, China (enrolling)
Full record on ClinicalTrials.gov
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