Microbiome Effect of Omadacycline on Healthy Volunteers

Completed · Phase 1

Conditions studied: Healthy Volunteers

In brief

The goal of this study is to assess microbiome changes associated with omadacycline vs. comparators (moxifloxacin or oral vancomycin). Using a phase I study design, healthy volunteers aged 18-40 years will be given a 10-day course of either omadacycline 450 mg days 1 and 2 followed by 300 mg PO once daily, moxifloxacin 400 mg once daily, or oral vancomycin 125 mg given four times daily. Stool will be collected at baseline, daily during therapy, and at two follow-up time periods (days 13-14 and days 30-32). DNA will be extracted from stool and used for qPCR biomass and microbial metagenomic experiments. Results from the study will provide definitive data on the microbiome effects of omadacycline versus comparator antibiotics.

Key facts

Study ID
NCT06030219
Run by
University of Houston
People needed
32
Starts
2020-10-12
Expected to finish
2023-09-01
Last updated by the study team
2025-03-25

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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